Bill & Melinda Gates Foundation:
The Bill & Melinda Gates Foundation is inviting proposals for the next round of Grand Challenges Explorations (GCE) for the following three challenges:
- Emerging Technologies for New Solutions in Global Health Priority Areas: We seek proposals that apply an emerging technology – or a combination of emerging technologies – for new and potentially transformative solutions in global health priority areas. These emerging technologies include – but are not limited to – artificial intelligence, materials science, wearable sensors, synthetic biology, nanotechnology, microscopy, augmented and virtual reality, geospatial mapping, robotics,and DNA sequencing. For background on the priority areas funded by the Bill & Melinda Gates foundation, please read the summaries of the strategies being employed by the teams within the global health division at the Gates foundation: Discovery & Translational Sciences; Enteric and Diarrheal Diseases; HIV; Malaria; Maternal, Newborn, and Child Health Discovery & Tools; Neglected Tropical Diseases, Pneumonia, Tuberculosis, and Vaccine Development and Surveillance. These priority areas encompass infectious disease outcomes, pregnancy and birth outcomes, child growth and development outcomes, disease surveillance, and research for the development of new vaccines, drugs (including non-hormonal contraceptives), and diagnostics.
- Environmental niches of Salmonella Typhi: In this new grand challenge, we solicit proposals to examine the environmental niches of S. Typhi. We are interested in understanding: (1) Survival of S. Typhi in the context of the soil and water microbiomes. S. Typhi survives for 3 weeks in the presence of castellani, but for no more than 10 days by itself (Frédéric Douesnard-Malo and Daigle 2011). Do interactions with other organisms impact survival of S. Typhi? How do they impact transmissibility of the bacterium? (2) Survival of S. Typhi within other organisms. Similar to V. cholerae, which thrives within zooplankton (Lipp, Huq, and Colwell 2002), does S. Typhi interact with aquatic multicellular organisms? If yes, how does this impact the transmission and epidemiology of typhoid? (3) Impact of environmental niches on the development of antibiotic resistance in S. Typhi. What is the relative amount of time S. Typhi spends in the environment compared to in infected individuals? How does this impact its exposure to antibiotics, and the development of antibiotic resistance in S. Typhi strains?
- Increasing Demand for Vaccination Services: Within this call to increase demand for vaccination services, and thus increase the number of children vaccinated globally, we are looking for innovative ideas in the following specific areas: (1) Novel approaches for providing practical knowledge about vaccines and vaccination services to caregivers; and (2) Novel ideas for improving the convenience and/or caregiver seeking of vaccination services.
- Initial grants are for USD $100,000 and successful projects are eligible to receive follow-on funding of up to USD $1 million.
- Applications are only two pages, and no preliminary data is required.
- Due date: April 10, 2019
Department of Energy (DOE):
ARPA-E issued a funding opportunity announcement (FOA) for the Design Intelligence Fostering Formidable Energy Reduction and Enabling Numerous Totally Impactful Advanced Technology Enhancements (DIFFERENTIATE) program, to accelerate the incorporation of machine learning and artificial intelligence into energy technology and product design processes. The DIFFERENTIATE program seeks to enhance energy innovation by incorporating artificial intelligence and machine learning into energy technology development. In order to organize these efforts, the program identifies six general mathematical optimization problems that are common to many design processes. It then conceptualizes several machine learning tools that could help engineers execute and solve these problems in a manner that dramatically accelerates the pace of energy innovation. DIFFERENTIATE projects will seek to develop enhanced machine learning tools. Proposals are expected to explicitly identify a selected challenge problem, an anticipated solution, a data acquisition strategy, major development risks, and an anticipated path to market for the final tool or software utility developed.
- Individual awards may vary between $250,000 and $5 million for up to 24 months.
- Concept papers due: 9:30 a.m. ET on May 20, 2019.
National Institute for Food and Agriculture (USDA-NIFA):
Applications to the FY 2019 Agriculture and Food Research Initiative – Sustainable Agricultural Systems (SAS) Request for Applications (RFA) must focus on approaches that promote transformational changes in the U.S. food and agriculture system within the next 25 years. NIFA seeks creative and visionary applications that take a systems approach, and that will significantly improve the supply of abundant, affordable, safe, nutritious, and accessible food, while providing sustainable opportunities for expansion of the bioeconomy through novel animal, crop, and forest products and supporting technologies. These approaches must demonstrate current and future social, behavioral, economic, health, and environmental impacts. Additionally, the outcomes of the work being proposed must result in societal benefits, including promotion of rural prosperity and enhancement of quality of life for those involved in food and agricultural value chains from production to utilization and consumption.
- Award: Up to $10,000,000 for up to 5 years.
- Please contact me if you are interested in applying to this program – proposal coordination assistance is available.
- Letters of Intent Due: Tuesday, June 4, 2019
The overall goal of the Organic Transitions Program (ORG) is to support the development and implementation of research, extension and higher education programs to improve the competitiveness of organic livestock and crop producers, as well as those who are adopting organic practices. NIFA administers the ORG program by determining priorities in U.S. agriculture through Agency stakeholder input processes in consultation with the NAREEEAB. ORG will continue to prioritize environmental services provided by organic farming systems in the area of soil conservation, pollinator health, and climate change mitigation, including greenhouse gases (GHG), as well as the development of educational tools for Cooperative Extension personnel and other agricultural professionals who advise producers on organic practices, and development of cultural practices and other allowable alternatives to substances recommended for removal from the National Organic Program’s National List of Allowed and Prohibited Substances. It is expected that all projects will integrate research, education and extension activities, as appropriate to project goals, although some projects may be weighted more heavily than others in one or more of these areas. However, all proposals should have activities and impact in research and at least one of the other areas: education and extension.
- Awards: Up to $500,000 for up to 3 years.
- Closing Date: Thursday, May 16, 2019 (FY 2019 funding cycle)
- Other Due Date: Thursday, February 27, 2020 (FY 2020 funding cycle)
National Institutes of Health (NIH):
The purpose of this Funding Opportunity Announcement (FOA) is to encourage the development of vaccines and other approaches for the prevention of Lyme disease and/or other tick-borne diseases.
- Awards: Application budgets are not limited but need to reflect the actual needs of the proposed project. Maximum project period is 5 years.
- Due: August 6, 2019.
Conduct Studies to Establish More Targeted Durations of Use for Certain Approved Antimicrobial New Animal Drugs in Food Animals (U01 Clinical Trial Required)
The purpose of this Funding Opportunity is to solicit applications to conduct studies that could support the approval of label changes to establish more targeted durations of use for certain approved medically important antimicrobial new animal drugs in food animals. These cooperative agreements are intended to provide publicly available data to be used by sponsor(s) of affected approved new animal drugs to support approval of future supplemental new animal drug applications. Such supplemental new animal drug applications are intended to:
1) Revise approved dosage regimens to provide for use durations that are more targeted (i.e., are more specifically defined) and,
2) That the revised dosage regimens continue to provide effectiveness that is comparable to the currently approved regimen while reducing the risk of antimicrobial resistance development.
- Awards: Up to $500,000 for 2 years.
- Due: June 3, 2019.
NIH Directors Pioneer Award Program (DP1 Clinical Trial Optional)
The NIH Director’s Pioneer Award Program supports individual scientists of exceptional creativity who propose highly innovative and potentially transformative research towards the ultimate goal of enhancing human health. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. Individuals from diverse backgrounds and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. To be considered pioneering, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigator’s research program or elsewhere. The NIH Director’s Pioneer Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.
- Awards: $700,000 in direct costs per year, plus applicable Facilities and Administrative (F&A) costs; award period is 5 years.
- Due: September 9, 2019.
NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional)
The NIH Director’s New Innovator Award Program supports early stage investigators of exceptional creativity who propose highly innovative research projects with the potential to produce a major impact on broad, important problems relevant to the mission of NIH. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. Individuals from diverse backgrounds and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director’s New Innovator Award Program complements ongoing efforts by NIH and its Institutes and Centers to fund early stage investigators through R01 grants, which continue to be the major sources of NIH support for early stage investigators. The NIH Director’s New Innovator Award Program is a component of the High-Risk, High-Reward Research Program of the NIH Common Fund.
- Awards: Up to 1,500,000 in direct costs per year, plus applicable Facilities and Administrative (F&A) costs; award period is 5 years.
- Due: August 26, 2019.
Novel RNAs in Virology (including HIV) and Immune Regulation: Basic Science and Therapeutic Discovery (R21 Clinical Trial Not Allowed)
The purpose of this Funding Opportunity Announcement (FOA) is to support basic science research, from early exploratory studies to therapeutic discovery and development, in novel biologically active viral and/or host RNAs involved in virology (including HIV biology) and immune regulation.
- Awards: $275,000 in direct costs for 2 years.
- Due: Standard dates apply. The first application due date for this FOA is June 16, 2019.
National Science Foundation (NSF):
The National Science Foundation (NSF) Division of Mathematical Sciences (DMS), in collaboration with the Division of Molecular and Cellular Biosciences (MCB), seeks to promote interdisciplinary research that enables novel mathematical and computational approaches that capture and explore the full range of mechanisms and biological variability needed to better understand biological systems behavior across multiple scales. The development of replicative or descriptive models for complex biological systems remains challenging. Models that move beyond replication into the realm of prediction and ultimately becoming indispensable tools for discovery-driven biology are severely lacking. A paradigm shift in the current, oftentimes conservative approach to interdisciplinary mathematical biology is needed to promote the realization of modeling platforms that facilitate discovery of novel biological phenomena, rules, and theories. As part of the effort, funding opportunities are available in fiscal years FY2019 and FY2020 to provide support for proposals from interdisciplinary teams comprised of mathematical, computational, and biological scientists to develop MODels for Uncovering Rules and Unexpected Phenomena in Biological Systems (MODULUS). This Dear Colleague Letter (DCL) is to encourage researchers involved in the biosciences and the mathematical sciences to collaborate formatively in biological investigations using novel mechanistic mathematical models to guide biological exploration and discovery of new rules in living systems.
The National Science Foundation invites interested parties to participate in a new endeavor, the NSF Convergence Accelerator (NSF C-Accel) Pilot. With this DCL, NSF’s goals are to: (i) pilot a new NSF capability (the NSF Convergence Accelerator) to accelerate use-inspired convergence research in areas of national importance, and (ii) initiate convergence team-building capacity around exploratory, potentially high-risk proposals in three convergence topics (tracks).As a funder of research and education across all fields of science and engineering and with relationships with universities and funding agencies around the world, NSF is uniquely positioned to pilot this approach to accelerate discovery and innovation. NSF C-Accel brings teams together to focus on grand challenges of national importance that require a convergence approach. The teams are multidisciplinary and leverage partnerships; the tracks relate to a grand challenge problem and have a high probability of resulting in deliverables that will benefit society within a fixed term. NSF C-Accel is modeled on acceleration and innovation activities from the most forward-looking companies and universities. The NSF C-Accel Pilot intends to support fundamental research while encouraging rapid advances through partnerships that include, or will include, multiple stakeholders (e.g., industry, academic, not-for-profits, government entities, and others). The NSF C-Accel Pilot will bring teams together in a cohort that are all focused on a common research goal of national importance but which may be pursuing many different approaches.
- NSF is planning to fund approximately 50 Phase 1 awards (up to 9 months and up to $1 million each). Additional funds will be available for a smaller number of Phase 2 awards.
- The first-step to become part of the NSF C-Accel Pilot is to submit a 2-page Research Concept Outline (RCO), aligned with one of the tracks described below, with a target submission date of April 15, 2019.
Limited Submission Opportunities (https://vpr.tamu.edu/initiate-research/lsp):
|*NEW* Brain Research Foundation: 2020 Scientific Innovations Award||04/26/2019||05/03/2019||06/25/2019|
|Mallinckrodt Foundation Grants||05/17/2019||05/24/2019||08/01/2019|
|NIH Data Science Research: Personal Health Libraries for Consumers and Patients||05/03/2019||05/10/2019||07/31/2019|
|Pew Biomedical Scholars||05/01/2019||05/08/2019||06/14/2019*|
|Conservation, Food & Health Foundation||04/17/2019||04/24/2019||07/01/2019|
|NSF Partnerships for Innovation – Research Partnerships||04/11/2019||04/18/2019||07/10/2019|